Alvaiz: Uses, Side Effects & Warnings

Generic name: Eltrombopag

Pregnancy & Lactation: Risk data not available

What is Alvaiz?

This medication guide is specific to the Alvaiz brand of eltrombopag. Do not use Alvaiz in place of other brands of eltrombopag.

Alvaiz is used to treat low platelet levels in adults and children at least 6 years old with chronic immune thrombocytopenia. Alvaiz is given after other treatments did not work or stopped working.

Alvaiz is used in adults to treat severe aplastic anemia after other treatments did not work or stopped working.

Alvaiz is also used to treat low platelet levels in the blood of adults with chronic hepatitis C before and during treatment with interferon.

Alvaiz is not to be used in people:

  • who have a pre-cancerous condition called myelodysplastic syndrome (MDS);
  • who have low platelet levels in blood (caused by certain other medical conditions or diseases); or
  • who need platelet levels to normalize.

Your doctor will determine if you are able to take Alvaiz.

Alvaiz may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor if you have or have ever had:

  • a blood clot;
  • pre-cancerous condition called myelodysplastic syndrome (MDS) or blood cancer;
  • bleeding or blood clotting disorder;
  • trouble swallowing;
  • cataracts;
  • a surgery to remove your spleen;
  • if you are of East or Southeast Asian descent;
  • to use any medicine to treat hepatitis C; or
  • liver disease.

It is not known if Alvaiz will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should still use effective birth control while using Alvaiz and for at least 7 days after your last dose.

Do not breastfeed while using this medicine.

How should I use Alvaiz

Use Alvaiz (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your dose needs may change if you switch to a different brand form of this medicine. Avoid medication errors by using exactly as directed on the label, or as prescribed by your doctor.

Alvaiz is usually taken once per day. Follow your doctor's instructions.

Swallow the tablet whole and do not crush, chew, or break it. Do not mix with food or liquids.

You may take Alvaiz with a meal (containing fewer than 50 milligrams of calcium) or without a meal. Learn about the foods you should eat or avoid.

Take Alvaiz at least 2 hours before or 4 hours after eating foods high in calcium (dairy products, calcium-fortified juices, certain fruits and vegetables). Follow all instructions of your doctor or dietitian.

You will need frequent vision exams and blood tests to check your liver function before and during treatment with Alvaiz. Your dose may be changed based on the results.

Your platelet levels will also need to be checked on a regular basis. Your bone marrow may be tested if you have severe aplastic anemia.

Do not change your dose or stop using Alvaiz suddenly. Ask your doctor before stopping the medicine.

Call your doctor if you have bleeding or bruising while using this medicine or after you stop taking Alvaiz.

Store this medicine in the original container at room temperature away from moisture and heat.

What should I do if I missed a dose of Alvaiz (Oral)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Alvaiz side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

You may develop a blood clot while you are using Alvaiz. Call your doctor or get emergency medical help if you have:

  • signs of a stroke--sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;
  • signs of a blood clot deep in the body--pain, swelling, or warmth in one leg; or
  • signs of a blood clot in the stomach--severe stomach pain, vomiting, diarrhea.

Call your doctor at once if you have any of these other side effects, even if they occur after your treatment ends.

  • easy bruising, unusual bleeding, pinpoint purple or red spots under your skin;
  • blurred or cloudy vision, seeing halos around lights, vision changes;
  • low red blood cells (anemia)--pale skin, tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • liver problems--confusion, tiredness, right-sided upper stomach pain, swelling around your midsection, dark urine, jaundice (yellowing of the skin or eyes).

Your treatment may be permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, diarrhea;
  • fever;
  • cough;
  • headache, tiredness;
  • low red blood cells (anemia); or
  • abnormal bone marrow or liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Alvaiz?

Ask your doctor before taking an antacid, and take only the type your doctor recommends.

Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.

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